| Megafine believes that Research and Innovation are the key success factors for the growth of the company. |
| Profile |
 |
 |
| The company’s R&D strengths are in creating intellectual property asset by developing non-infringing, novel, cost effective and environmentally friendly processes for API’s and finding easier solutions to complex chemistry challenges. We are specialized in constructing chiral molecules with strong expertise and experience in the resolution processes. | ||
| Our R&D team consists of more than 40 qualified scientists with extensive expertise and experience in Process Research and Development activities for API’s and their critical intermediates. | ||
| Our main philosophy is backward integration of API’s synthesis starting from basic raw material, thereby being self dependent for critical intermediates to control the cost and quality. | ||
| Solid state studies, particularly polymorphism and particle size are proving to be bottle neck in marketing newer API’s. At Megafine, scientists are skilled in providing the solutions to the problems associated with them. | ||
| We have two research centers, one at Nashik, Maharashtra, India and another at Vapi, Gujarat, India. R&D center at Vapi is mainly focused to provide critical intermediates with high purity and low cost through intensive research to our main R&D center at Nashik and as well as to API manufacturers around the globe. | ||
| A well equipped R&D center is supported by kilo lab having reactors from 5 lit to 250 lit, SSR/GLR vessels to solve scale-up issues at production. | ||
| We are very specific in creating online documentations for various phases of process development including the scale-up, safety, and engineering reports which help production to have the safe and robust process and to support regulatory filings. | ||
| Process R&D Laboratories and Scale-up facilities |
|
|
 |
Well equipped R&D centre with the state of the art facilities | |||||
|
|
Process development and continuous improvement to meet the cost | |||||
|
|
Innovative chemical research and process development for new APIs | |||||
|
|
Technology Transfer Team for smooth transfer of process from R&D to Manufacturing through Pilot Plant | |||||
|
|
Experts in evaluating Polymorphs | |||||
|
|
Polymorph synthesis and characterization | |||||
|
|
Robust Process Development guidelines and reports | |||||
|
|
Wide Reaction capabilities few of which includes; | |||||
 |
Alkylation |
|
Halogenations | |||
|
|
Amidation |
|
Hydrazine Chemistry | |||
|
|
Condensation |
|
Hydrogenation | |||
|
|
Cyanations |
|
Nitrations | |||
|
|
Cryogenic Reactions |
|
Oxidations | |||
|
|
Etherification |
|
Piperazines | |||
|
|
Esterifications |
|
Reductions | |||
|
|
Formylation |
|
Resolution Tech | |||
|
|
Friedel Crafts Reaction |
|
Thiophene | |||
|
|
Grignard Reaction |
|
Witting | |||
|
|
Swern’s oxidation |
|
Gewald | |||
| Analytical R&D |
|
|
|
|
Skilled & experienced manpower with well equipped laboratories having HPLC (with PDA, UV, & RI detector), GC, GC-HS, UV, IR, Polarimeter, Potentiometer, KF titrator etc | ||
|
|
Analytical Method development and Method validations | ||
|
|
Impurity profiling and degradation studies | ||
| Intellectual Property Management |
|
|
|
|
Respect for IP | ||
|
|
Patents landscaping | ||
|
|
Developing Non-infringing and Cost Competitive Schemes | ||
|
|
Filing Patents | ||
|
|
Providing NI opinions | ||
|
|
Research publications | ||