crams
Contract Research and Manufacturing Services (CRAMS) by Megafine encompasses a set of services for Custom Synthesis, Process R&D, Scale up, Contract/toll Manufacturing of APIs, Advance Intermediates, Key Building blocks for in-market products and for NCEs from early phase development to commercialization stage.
Megafine with it’s integrated R&D, technology and engineering capability has served as a dependable manufacturer to leading Innovators and several Global Pharma majors by developing cost effective and non-infringing processes for various APIs & Advance Intermediates. Respect for IPR and Customer Confidentiality is a management philosophy.
| OUR CORE STRENGTHS |
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Custom Research and Manufacturing Services of Megafine combines: |
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Decades of chemistry experience in the pharmaceutical industry
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A long & proven track record and strong relationship with top global pharmaceutical innovators and generic players |
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Unmatched experience and leadership in piperazine chemistry
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Expertise in wide range of chemical reaction and technology platforms
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Strong R&D, Engineering & Manufacturing
capabilities across the scale of operation, from lab to pilot to
plant execution for smooth scale up & commercial production |
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Facilities complying cGMP |
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Total quality management |
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Environment, Health and Safety is key management philosophy
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Focused regulatory support |
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Robust solutions to our customers on time, every time |
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An efficient logistics and supply chain |
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A dedicated project management team
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| SALIENT FEATURES |
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Site area 300,000 sq. ft. |
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Total plant area 50,000 sq. ft. |
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SIX multipurpose manufacturing blocks with THREE cGMP
API streams |
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APIs manufactured under class 100,000 |
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Intermediates manufacturing area with 5 micron
filter |
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Process water to meet USP standards |
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Total reaction capacity: 90,000 liters |
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SS, GL reactors ranging from 10 to 8000 liters |
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Multiple drying options |
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Fractional & FFE Distillation under high vacuum |
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Temperature range (-) 80⁰C to 275⁰C |
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Pressure upto 145 psi |
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Nitrogen blanketing system |
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PLC based automation system for hazardous operations
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| REACTION CAPABILITIES |
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Alkylations
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Halogenations
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Amidations
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Hydrazine
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Condensation
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Hydrogenation
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Cyanations
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Nitrations
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Cryogenic
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Oxidations
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Etherification
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Piperazines
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Esterifications
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Reductions
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Formylation
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Resolution Tech.
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Friedel Crafts
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Thiophene
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Grignard
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Witting
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Swern’s oxidation
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Gewald
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